Aquaretic Effect of Lixivaptan, an Oral, Non-Peptide, Selective V2 Receptor Vasopressin Antagonist, in New York Heart Association Functional Class II and III Chronic Heart Failure Patients
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چکیده
منابع مشابه
Aquaretic effect of lixivaptan, an oral, non-peptide, selective V2 receptor vasopressin antagonist, in New York Heart Association functional class II and III chronic heart failure patients.
OBJECTIVES The purpose of this study was to examine the renal effects of a V2 receptor arginine vasopressin (AVP) antagonist in heart failure. BACKGROUND Arginine vasopressin has been implicated in the renal water retention and dilutional hyponatremia associated with chronic heart failure. METHODS We examined the effects of the oral, non-peptide, selective V2 receptor antagonist lixivaptan ...
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Aquaporin-2 (AQP-2), a water channel located on the apical membrane of collecting duct cells, regulates water reabsorption under the control of vasopressin (AVP). Using an antibody directed to human AQP-2, a quantitative Western blot analysis was performed to determine the collecting duct responsiveness to an oral, nonpeptide, V2 receptor antagonist (VPA-985) in patients with chronic NYHA II an...
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It has been firmly established that cardiac resynchronization therapy (CRT) reduces symptoms and decreases morbidity and mortality1–6 in a subgroup of patients who remain in moderate to severe chronic heart failure (HF) (New York Heart Association [NYHA] class III/IV) despite optimal medication. These patients are characterized by wide QRS on the surface ECG as a sign of ventricular dyssynchron...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2006
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2005.11.071